FAK anticorps (pSer843)

N° du produit ABIN7138762

Cet anticorps anti-FAK est un anticorps Lapin Polyclonal détectant FAK dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour FAK anticorps (pSer843) (ABIN7138762)

Antigène: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAK est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-FAK anticorps

Épitope: pSer843

Fonction: Phospho-PTK2 (Ser843) Antibody

Réactivité croisée: Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of serine843(R-G-S(p)-I-D) derived from Human FAK .

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FAK

Antigène: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Autre désignation: PTK2

Sujet:

Background:

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

Jiang X, Sinnett-Smith J, Rozengurt E (2007)Cell Signal 19, 1000-10 . Jacamo R, Jiang X, Lunn JA, Rozengurt E (2007)J Cell Physiol 210, 436-44. Le Boeuf F, Houle F, Sussman M, Huot J (2006)Mol Biol Cell 17, 3508-20 .

Aliases: FADK 1 antibody, FADK antibody, FAK related non kinase polypeptide antibody, FAK1 antibody, FAK1_HUMAN antibody, Focal adhesion kinase 1 antibody, Focal adhesion Kinase antibody, Focal adhesion kinase isoform FAK Del33 antibody, Focal adhesion kinase related nonkinase antibody, FRNK antibody, p125FAK antibody, pp125FAK antibody, PPP1R71 antibody, Protein phosphatase 1 regulatory subunit 71 antibody, Protein tyrosine kinase 2 antibody, Protein-tyrosine kinase 2 antibody, Ptk2 antibody, PTK2 protein tyrosine kinase 2 antibody

UniProt: Q05397

Pathways: Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling